My research program adopts a broad and integrative approach to the study of chronic musculoskeletal pain, incorporating both basic and clinical sciences. A major arm to my research program is investigating the underlying pathophysiologic mechanisms using both animal and human models. My research also aims to advance reliable diagnostic criteria (imaging, biomarkers) and physical assessment techniques (quantitative sensory testing, electromyography) that enable effective and reliable treatment and management strategies. By emphasizing transdisciplinary and multi-institutional collaborations, my research program will continue to inform future clinical and experimental initiatives in the field of chronic musculoskeletal pain.Learn More
Department: Human Health and Nutritional Sciences
My research is focused on the biological effects of functional foods on chronic disease-related endpoints evaluated in human intervention studies. I have a focus on the agri-food-health continuum with a particular interest in studying the health effects of agri-foods such as soybeans, lentils and beans. I am interested in studies in all life-stages, however am actively involved with the Guelph Family Health Study (focus on families with young children) and with Agri-Food for Healthy Aging (focus on older adults). I am also interested in examining how different sub-groups perceive and consume functional foods as examined through comprehensive questionnaires.Learn More
More than 4 million Canadians have arthritis and the number of people living with arthritis continues to increase year after year. Osteoarthritis involves multiple tissues and often includes cartilage damage, bone sclerosis and synovial inflammation. A pressing need remains for joint localized therapies and interventions that could slow or ideally stop this debilitating disease.
In our research, we use genetic and surgical models of spontaneous osteoarthritis (with old age) and post-traumatic osteoarthritis (following injury). We follow the progression of disease in a joint in order to better understand how proteins such as TRPV4, integrin alpha1beta1 and cilia influence chondrocyte signal transduction and thus the development of osteoarthritis.
Currently, there are several major areas of research focus including the study of basic fatty acid metabolism, understanding the association between plasma fatty acids and health outcomes, omega-3 fatty acids in the prevention of breast cancer, and examining determinants of health in the Guelph Family Health Study. In addition, related projects include the study of fats in brain health (concussion, Alzheimer's Disease), fatty liver disease, fatty acid metabolism, bone development and nutrigenomics.Learn More
My interest in clinical biomechanics and neurophysiology evolved during my years as a primary health care provider in chiropractic and acupuncture. Over two decades of clinical observation underscored the fact that these, and other commonly adopted conservative clinical therapies/interventions, have a profound impact on human physiology, the scope and mechanisms of which are still poorly characterized. I began private practice in 1992 where I quickly developed a fascination for the clinical enigma of chronic musculoskeletal pain, the most common form of which being chronic myofascial pain.
My research program adopts a broad and integrative approach to the study of chronic musculoskeletal pain, incorporating both basic and clinical sciences. A major arm to my research program is investigatLearn More
Skeletal muscle is a remarkable tissue which regulates many metabolic processes, generates heat and is the basic motor of locomotion allowing us to meaningfully interact with our environment. When a muscle is activated at various lengths it produces a given predictable amount of force. However, when that muscle is actively lengthened or shortened those predictions go out the window. We actually know very little regarding dynamic muscle contraction. My research program focuses on muscle contractile properties and gaining a deeper understanding of how muscle works. I use altered states to tease out some of these fine muscle details such as: Muscle fatigue, Aging, And Training.Learn More
Our research centres on the application of physical activity and other acute/chronic perturbations to human physiology to understand how and why the body adapts to these stresses. We take an integrative systems approach, with our work focusing on interventions and assessments of cardiovascular, respiratory and muscular physiology. Specific focus areas include projects to understand the effects peripheral blood flow manipulation, the consequences of particularly stressful exercise, and novel training methods to optimize targetted physiological adaptations. From a health perspective, we are interested in understanding how exercise can be used to prevent and control risk factors for cardiovascular and cardiometabolic disease.Learn More
Dysfunctional lipid metabolism is a key feature of cardiometabolic diseases, such as obesity and type 2 diabetes. My research program has three primary areas of interest:
First, we are using cell and mouse models to determine how omega-3 fats regulate lipid metabolism. We are investigating how omega-3 fats control adipogenesis, as well as lipogenic, lipolytic, and triglyceride synthesis pathways in adipose tissue and liver.
Second, we are studying how different nutrients regulate omega-3 synthesis in the body using both mouse models and human clinical trials.
Third, we are interested to personalize nutrition to improve human cardiometabolic health (PMID: 30472712, 29400991, 28272299). We continue to be active in this area through various national and international collaborations.Learn More
The role of physical properties in determining the metabolic and health effects of foods is often overlooked. We aim to better understand the relationships between food properties and metabolic response, particularly for dietary lipids. After chemical and structural analyses, real and model food systems are exposed to simulated gastrointestinal conditions using static and dynamic models. This generates insight into how food properties interact with the biochemical and biophysical aspects of digestion to determine nutrient release and absorption. We couple these experimental approaches with human clinical trials to relate material properties and their digestive behavior with metabolic endpoints (e.g. absorption, satiety, inflammation, lipemia, gastrointestinal symptoms).Learn More