Andrea Clark

Email Address
[email protected]
Research Description

cell mechanotransduction

Research Summary

More than 4 million Canadians have arthritis and the number of people living with arthritis continues to increase year after year. Osteoarthritis involves multiple tissues and often includes cartilage damage, bone sclerosis and synovial inflammation. A pressing need remains for joint localized therapies and interventions that could slow or ideally stop this debilitating disease.
In our research, we use genetic and surgical models of spontaneous osteoarthritis (with old age) and post-traumatic osteoarthritis (following injury). We follow the progression of disease in a joint in order to better understand how proteins such as TRPV4, integrin alpha1beta1 and cilia influence chondrocyte signal transduction and thus the development of osteoarthritis.

Techniques Used

Genetic mouse models, confocal microscopy, histology, immunohistochemistry, immunofluorescence, reverse transcriptase polymerase chain reaction, gel electrophoresis, micro-computed tomography.

Lab Equipment

Vanderbilt University, Tennessee USA

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