- Department
- Email Address
- [email protected]
- Research Areas
- Research Keywords
- Research Description
I aim to understand the molecular and cellular relationships that underlie neurological dysfunction during developmental or regenerative processes within the central nervous system. I am interested by the intercellular interactions between neuronal and non-neuronal (glial) cells, and how these interactions govern plasticity as the system develops, ages, or is inflicted by trauma or disease.
- Research Summary
Overall, my research program takes an integrative and comparative approach to study glial-neuronal interactions in relation to early development, physical injury, and neurological disease that spans across multiple levels of biological organization (molecular and cellular physiology > systems biology) and multiple model species (zebrafish and mice).
Our two areas of focus are:
1) investigation of glial-mediated mechanisms underlying development and disease;
2) exploration of naturally adaptive models with significant recovery from, or tolerance to, neurological stress or disease.- Techniques Used
Mouse and zebrafish animal models, patient-derived (human) and primary (mouse) cell culture, live cell imaging, histological analysis, molecular assays, neuronal recordings, behavioural analysis.
- Links