- Email Address
- [email protected]
- Research Description
In my lab, we aim to understand the mechanisms and consequences of recombination in mammalian cells. Recombination is a process by which genetic information is exchanged between DNA duplexes. In particular, we are interested in studying the association between recombination and the development of cancer and other diseases.
- Research Summary
The three research goals of my laboratory are: 1) to understand the molecular genetic mechanisms of recombination in mammalian cells; 2) to understand how defects in recombination contribute to tumorigenesis; and, 3) to understand the nature of recombination hotspots. We are presently researching questions pertaining to: the mechanism and frequency of recombination in mammalian cells; the role of large palindromes in promoting recombination within and between mammalian chromosomes; mammalian heteroduplex DNA formation and repair during recombination; genetics of strand invasion and 3' end polymerization; how DNA sequences act to stimulate recombination; non-crossover mechanisms of homologous recombination; the genetic control of recombination (investigation of the role of the Rad52 epistasis group of genes, and the Breast Cancer 2 tumor suppressor gene, BRCA2).
- Techniques Used
Techniques in recombinant DNA/molecular genetics, immunological and immunochemical techniques, techniques in somatic cell genetics