Mark Baker

Email Address
[email protected]
Research Description

In my lab, we aim to understand the mechanisms and consequences of recombination in mammalian cells. Recombination is a process by which genetic information is exchanged between DNA duplexes. In particular, we are interested in studying the association between recombination and the development of cancer and other diseases.

Research Summary

The three research goals of my laboratory are: 1) to understand the molecular genetic mechanisms of recombination in mammalian cells; 2) to understand how defects in recombination contribute to tumorigenesis; and, 3) to understand the nature of recombination hotspots. We are presently researching questions pertaining to: the mechanism and frequency of recombination in mammalian cells; the role of large palindromes in promoting recombination within and between mammalian chromosomes; mammalian heteroduplex DNA formation and repair during recombination; genetics of strand invasion and 3' end polymerization; how DNA sequences act to stimulate recombination; non-crossover mechanisms of homologous recombination; the genetic control of recombination (investigation of the role of the Rad52 epistasis group of genes, and the Breast Cancer 2 tumor suppressor gene, BRCA2).

Techniques Used

Techniques in recombinant DNA/molecular genetics, immunological and immunochemical techniques, techniques in somatic cell genetics

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