Melissa Perreault

Department
Email Address
[email protected]
Research Areas
Research Keywords
Research Description

The Perreault lab uses rodent models of neuropsychiatric disorders to determine how brain wave patterns are dysregulated in these disorders and link to disorder symptoms. Sex differences in these patterns and the mechanisms that underlie their dysregulation is also examined.

Research Summary

In our laboratory we use multiple advanced techniques to take an integrative approach to research that involves combining cell and systems research with animal behaviour to help us gain insights into the mechanisms that underlie neurological disorders. At present our primary research focuses are in depression, schizophrenia, autism, and Alzheimer’s disease, with a specific interest in understanding sex differences in neuropathology and treatment response. To achieve this we use pharmacological, pharmacogenetic and behavioural techniques combined with electrophysiology and computational algorithms to evaluate how neuronal network communication is impaired is these models, and to determine the cell signaling pathways responsible for the network disruption.

Techniques Used

In vivo and in vitro systems electrophysiology, custom made 8 channel electrode arrays, deep brain stimulation, viral vectors, rodent behaviour, Western Blotting, immunohistochemistry, fluorescence microscopy, primary neuronal cell culture, quantitative PCR, pharmacological manipulations.

Lab Equipment

Wireless electrophysiology setup, Axion multielectrode array reader, Western Blotting apparatus, Etaluma fluorescence microscope, behavioural apparatus (elevated plus maze, water maze, open field, T-maze), Biobubble

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