- Department
- Email Address
- [email protected]
- Research Areas
- Research Keywords
- Research Description
My lab studies how eukaryotic cells interact with microorganisms. Specifically, we look at cell surface receptors and their interaction with host- and microbe-derived ligands to elucidate mechanisms of host immune responses in homeostasis and disease.
- Research Summary
We are interested in understanding how mast cells recognize beneficial and pathogenic microbes to maintain tissue homeostasis and educate the immune system. Our lab uses an interdisciplinary approach that combines mouse and microbial genetics, receptor pharmacology, sequencing, multiparameter flow cytometry, microscopy, and infection models to elucidate how the G protein-coupled receptors expressed by mast cells act as sensors of the communication between host and microbes. Our ultimate goal is to guide fundamental knowledge necessary for developing next-generation therapeutics for infectious and inflammatory diseases.
- Techniques Used
Mouse and microbial genetics, receptor pharmacology, sequencing, multiparameter flow cytometry, microscopy, and infection models.
- Locations of international collaborators
Johns Hopkins University, EmoryUniversity (USA); Xi’an Jiaotong University (China); Universite de Toulouse (France).
- Links