- Email Address
- [email protected]
- Research Description
My lab studies structure and dynamic properties of membrane and soluble proteins in cells. In particular, I do research on diseases caused by bacteria and look at how these different proteins in the bacteria give them greater or lesser ability to colonize their host.
- Research Summary
My research is in the general area of protein structure and dynamics and is specifically focused on the biochemistry of bacterial toxins involved in disease and consists of the following projects: Membrane structure of the colicin E1 ion channel; data mining and bioinformatics of bacterial virulence factors; optical spectroscopic approaches to study protein structure and dynamics; enzyme reaction mechanism of the bacterial mono-ADP-ribosyltransferase family; inhibition mechanisms and structural complexes of toxins with inhibitors; and, X-ray structures of protein-protein complexes involving toxins.
- Techniques Used
Data mining and bioinformatics; optical spectroscopic approaches.