Work in the Gillis lab is focused on the vertebrate heart and the mechanisms that regulate it’s function and ability to remodel in response to a physiological stressor. Current projects include characterizing the capacity of the hagfish heart to work in anoxia (no oxygen), examining developmental plasticity in the alligator heart, and determining the influence of bitumen (crude oil) exposure on cardiac histology and function in salmonid fish.Learn More
Keyword: Cell Biology and Genetics
We are interested in characterizing the mechanisms of pathogenesis, adaptation, and survival in fungal and bacterial microbes from a systems biology perspective through mass spectrometry-based quantitative proteomics. Specifically, research in the lab centres around the following areas:
1. Systems biology to elucidate microbial proteome dynamics and interactions;
2. Mechanistic characterization of pathogenic proteins; and
3. Mass spectrometry-based proteomics for drug discovery and repurposing.
Our long-term goals emphasize the utilization of mass spectrometry-based proteomics to fundamentally understand differential microbial adaptation and survival strategies and to integrate a novel systems biology platform for investigation of diverse biological systems.