Many of the signaling pathways that are involved in development are also involved in the onset and progression of disease. As an example, the Wnt signaling pathway is required during many stages of development and in the homeostasis of stem cells in the adult. Perturbation of this pathway in stem cells in the adult often leads to cancer. It is now known that greater than 90% of colorectal cancers are caused by mutations in the Wnt signaling pathway. As this pathway is important for both proper development and disease, I am curious to know how this pathway can turn it self on and off so many times during development and why it fails to turn off in disease. The lab focuses on two negative feedback regulators of Wnt signaling: Nkd1 and Axin2.Learn More
Keyword: Developmental biology
My research focuses on asymmetric RNA localization and localized translational control in animal species. I have also studied asymmetric RNA localization in neural stem cells and their contribution to both cellular differentiation and cortical development across species. Currently, my students and I are investigating various proteins that we think are important for RNA regulation during brain development.Learn More
The ecological and evolutionary problems that underlie my research interests include the convergent evolution of morphology, the manner by which organisms have adapted to their physical environment, physical aspects of energy transfer through ecosystems, and physical-biological linkages in aquatic systems. My lab is currently examining the physical ecology of trophic interactions, reproduction (including abiotic pollination and broadcast spawning), physical-biological interactions and larval recruitment, limnological processes involving hypoxia, hydrological processes involving benthic organisms, and sediment/substrate-water interactions.Learn More
Our research is focused on identifying and understanding the pathways by which environmental and social stressors are perceived, processed, and transduced into a neuroendocrine response. Several projects are aimed at elucidating how the neuroendocrine system orchestrates the stress response and focused specifically on the physiological functions of the corticotropin-releasing factor (CRF) system. Another major focus of the lab is to investigate the interactions between the neuroendocrine pathways that regulate the stress response and those involved in the regulation of appetite and growth.Learn More
My lab focuses on two main axes of research:
1) Unfolded Protein Response and Human Diseases: We study proteins that play key roles in animal stress responses, specifically the Unfolded Protein Response (UPR), which has been linked to animal development, cell differentiation, as well as a variety of human diseases such as Alzheimer’s, diabetes, cancer and viral infection.
2) Molecular Mechanisms of Aging: We are working to establish planarians as a new aging model to test the hypothesis that longevity requires multiplex resistance to stress. We hope to identify genes or alleles that confer such multiplex stress resistance and/or promote longevity.
Current projects include:
- Mechanistic and functional connections between stress and adult neurogenesis in fish
- Effects of aquatic pollutants on fish physiology, morphology, and performance
- Neuroanatomy and regenerative capacity of the hagfish brain
- Quantitative proteomics as a tool for biomarker discovery and novel insights into animal physiology
The growth of neurons and their organization into circuits is a tightly controlled process that follows a series of well-defined steps. Once differentiated and integrated into networks, neurons also retain a remarkable capacity to rapidly change the arrangement of their connections in response to activity, a feature that is believed to critically support cognition as well as our ability to learn and retain information for long periods of time. Accumulating evidence strongly suggests that perturbation of the molecular interactions responsible for the growth of neurons, or the capacity of these cells to adequately respond to activity-dependent signals, contributes to the pathophysiology of different brain disorders. Our laboratory uses a multidisciplinary approach to explore these questions.Learn More
Dr. Heyland's laboratory uses novel functional genomics approaches to study the endocrine and neuroendocrine systems of aquatic invertebrates. Specifically he investigates the function and evolution of hormonal and neurotransmitter signaling systems in the regulation of development and metamorphosis. His research includes evolutionary development studies of marine invertebrate metamorphosis, eco-toxicogenomic approached to understand endocrine disruption in aquatic ecosystems and water remediation technologies. These projects are integrated with several national and international collaborations ranging form basic scientific work to industry partnerships.Learn More
Ongoing projects include:
1) Examining cardiac remodeling in zebrafish and trout in response to thermal acclimation.
2) Characterizing the role of the troponin complex in regulating the function of striated muscle.
3) Examining the function of the hagfish heart during prolonged anoxia exposure.
4) Examining the change in diaphragm function during the onset of heart failure.
5) Characterizing how bitumen exposure of sockeye salmon early life stages influences cardiac development and aerobic fitness.