Keyword: Fungi

Rebecca Shapiro

To better study the biology and virulence of fungal pathogens, we are developing new genomic technology platforms for diverse fungal species. We are exploiting CRISPR-Cas9 based technologies to revolutionize the way we do high-throughput functional genomic analysis in fungal pathogens. This is enabling us to map large-scale genetic interaction networks, and uncover genetic factors and pathways that mediate important phenotypes associated with pathogenesis, antifungal drug resistance, and other biological processes associated with fungal infectious diseases.

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Rebecca Shapiro

We are interested in understanding complicated genetic networks in fungal pathogens. Focusing primarily on the common yeast pathogen Candida albicans and the emerging pathogen Candida auris, our lab is developing and optimizing novel CRISPR based functional genomic technologies and using them to modulate the fungal genome on a large scale. We are applying these technologies for large-scale functional genomic screening, in order to understand the genes and genetic interactions that underly fungal pathogenesis (including cellular morphogenesis and biofilm formation), the evolution of antifungal drug resistance.

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Stephen Seah

We are interested in microbial enzymes involved in the steroid and aromatic compounds degradation. These enzymes are important for bioremediation of organic pollutants and are potential targets for development of antibiotics against tuberculosis. In collaboration with Dr. Ting Zhou at Agriculture Agri-food Canada, we are isolating and characterizing enzymes capable of detoxifying the mycotoxins, deoxynivalenol and patulin. These mycotoxins contaminate grains and fruit juices.

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