David Mutch

Dysfunctional lipid metabolism is a key feature of cardiometabolic diseases, such as obesity and type 2 diabetes. My research program has three primary areas of interest:

First, we are using cell and mouse models to determine how omega-3 fats regulate lipid metabolism. We are investigating how omega-3 fats control adipogenesis, as well as lipogenic, lipolytic, and triglyceride synthesis pathways in adipose tissue and liver.

Second, we are studying how different nutrients regulate omega-3 synthesis in the body using both mouse models and human clinical trials.

Third, we are interested to personalize nutrition to improve human cardiometabolic health (PMID: 30472712, 29400991, 28272299). We continue to be active in this area through various national and international collaborations.

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