Keyword: Lifestyle interventions to promote health

Kerry Ritchie

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I conduct research in two areas:
1) Impact of teaching strategies on student learning and engagement in large classes: My goal is to modify and scale best teaching practices to suit large class sizes (100-600+ students). I evaluate the impact of these strategies on student learning and engagement. I am also interested in novel methods for teaching critical thinking and communication skills in health sciences education.
2) Health and performance of emerging adults in the early transition to university: I aim to better understand student experience to develop programs and strategies to optimize student performance. I study how lifestyle choices, social environments, and study strategies can influence student wellbeing and academic success.

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Lindsay Robinson

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I am interested in understanding the physiological roles and regulation of adipose tissue and skeletal muscle-derived cytokines in mediating metabolic processes in the body. I am particularly interested in the mechanisms by which dietary factors and/or exercise modulate various cytokines and inflammatory mediators implicated in insulin resistance, a key characteristic of obesity and type 2 diabetes. My current research projects are:
1) Regulation of adipose tissue-derived cytokines in integrative metabolism.
2) Effect of n-3 and n-6 fatty acids in the presence and absence of LPS on adipocyte secretory factors and underlying mechanisms.
3) Effect of dietary fatty acids on pro-inflammatory markers in an in vitro murine adipocyte macrophage co-culture model.

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David Wright

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Since changes in how the body metabolizes glucose are a hallmark of Type 2 diabetes, understanding how the function and metabolism of adipose tissue are regulated will be crucial for understanding diabetes itself. My students and I look at how exercise and nutritional interventions affect gene expression in adipose tissue, and, in turn, how these changes can affect both adipose tissue metabolism and whole-body glucose metabolism. One of the applications of my research is to potentially develop new, non-drug-based approaches that can be used to prevent and/or reverse Type 2 diabetes.

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Alison Duncan

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My research is focused on the biological effects of functional foods on chronic disease-related endpoints evaluated in human intervention studies. I have a focus on the agri-food-health continuum with a particular interest in studying the health effects of agri-foods such as soybeans, lentils and beans. I am interested in studies in all life-stages, however am actively involved with the Guelph Family Health Study (focus on families with young children) and with Agri-Food for Healthy Aging (focus on older adults). I am also interested in examining how different sub-groups perceive and consume functional foods as examined through comprehensive questionnaires.

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David Ma

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Currently, there are several major areas of research focus including the study of basic fatty acid metabolism, understanding the association between plasma fatty acids and health outcomes, omega-3 fatty acids in the prevention of breast cancer, and examining determinants of health in the Guelph Family Health Study. In addition, related projects include the study of fats in brain health (concussion, Alzheimer's Disease), fatty liver disease, fatty acid metabolism, bone development and nutrigenomics.

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Jamie Burr

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Our research centres on the application of physical activity and other acute/chronic perturbations to human physiology to understand how and why the body adapts to these stresses. We take an integrative systems approach, with our work focusing on interventions and assessments of cardiovascular, respiratory and muscular physiology. Specific focus areas include projects to understand the effects peripheral blood flow manipulation, the consequences of particularly stressful exercise, and novel training methods to optimize targetted physiological adaptations. From a health perspective, we are interested in understanding how exercise can be used to prevent and control risk factors for cardiovascular and cardiometabolic disease.

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David Mutch

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Dysfunctional lipid metabolism is a key feature of cardiometabolic diseases, such as obesity and type 2 diabetes. My research program has three primary areas of interest:
First, we are using cell and mouse models to determine how omega-3 fats regulate lipid metabolism. We are investigating how omega-3 fats control adipogenesis, as well as lipogenic, lipolytic, and triglyceride synthesis pathways in adipose tissue and liver.
Second, we are studying how different nutrients regulate omega-3 synthesis in the body using both mouse models and human clinical trials.
Third, we are interested to personalize nutrition to improve human cardiometabolic health. We continue to be active in this area through various national and international collaborations.

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Stephen Brown

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Our research is dedicated to understanding mechanisms that dictate healthy function of the human spine, and ultimately the causes and consequences of low back injury and pain. To do this we study the mechanics and physiology of the lumbar spine and its musculature. We use both human and animal models to understand different aspects of how spine movement is achieved and what "normal" movement looks like, the role of muscle in producing this movement and stabilizing the spine, and how the spine and muscle both adapt to injury and how they can be rehabilitated from injury.

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Philip Millar

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The primary aim of my research is to better understand the mechanisms that control, and functional consequences of, sympathetic outflow at rest and during stress in humans with and without cardiovascular disease. To uncover these mechanisms, my laboratory employs direct intra-neural recordings of postganglionic sympathetic traffic, studying both multi- and single-fibre preparations. Additionally, we are also interested in understanding the mechanisms responsible for the large inter-individual variability in blood pressure responses to stress, as well as testing novel interventions to reduce resting blood pressure, a major modifiable risk factor for cardiovascular disease.

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