In our laboratory we use multiple advanced techniques to take an integrative approach to research that involves combining cell and systems research with animal behaviour to help us gain insights into the mechanisms that underlie neurological disorders. At present our primary research focuses are in depression, schizophrenia, autism, and Alzheimer’s disease, with a specific interest in understanding sex differences in neuropathology and treatment response. To achieve this we use pharmacological, pharmacogenetic and behavioural techniques combined with electrophysiology and computational algorithms to evaluate how neuronal network communication is impaired is these models, and to determine the cell signaling pathways responsible for the network disruption.Learn More
My human research program has three primary areas of interest.
First, we are using single-unit muscle sympathetic nerve recordings to understand the organization and regulation of the sympathetic nervous system in response to a stress. We have shown (PMID: 30388036) the capacity for differential control of postganlionic sympathetic single units directed towards skeletal muscle.
Second, we are determining the mechanisms responsible for inter-individual variability in blood pressure responses to exercise. We have made key contributions to determining the role of genetic variants and muscle strength in this area (PMID: 30206938; 29135658).
Third, we study the clinical utility of exercise rehabilitation and are currently conducting a exercise training study in patients with Parkinson's.