Keyword: neurobiology

Shaun Sanders

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The Sanders lab is interested in how neurons use the protein-lipid modification palmitoylation to target proteins to subcellular locations and to define how palmitoylation-dependent targeting contributes to physiological neuronal function and neuropathological conditions. Current projects include characterizing how palmitoylation of vesicular transport machinery regulates fast axonal transport and how palmitoylation of ion channels and their scaffold proteins regulates clustering at the axon initial segment, a critical site of neuronal excitability where action potentials are generated.

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Jasmin Lalonde

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The growth of neurons and their organization into circuits is a tightly controlled process that follows a series of well-defined steps. Once differentiated and integrated into networks, neurons also retain a remarkable capacity to rapidly change the arrangement of their connections in response to activity, a feature that is believed to critically support cognition as well as our ability to learn and retain information for long periods of time. Accumulating evidence strongly suggests that perturbation of the molecular interactions responsible for the growth of neurons, or the capacity of these cells to adequately respond to activity-dependent signals, contributes to the pathophysiology of different brain disorders. Our laboratory uses a multidisciplinary approach to explore these questions.

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Frederic Laberge

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Work in the Laberge lab attempts to understand how variation in brain structure and size influences organismic function, and identify the factors that drive evolution and plasticity of the nervous system. Current projects on this topic study variation in structure and size of the brain in populations of fish and amphibians, the proximate mechanisms generating this variation, and the functional consequences of this variation. Additionally, the lab is involved in collaborative efforts aiming to develop novel indicators of ecological performance and chronic stress in wild fish.

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