Keyword: Antimicrobial drug resistance

Cullen Myers

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Our current research projects focus on:
- The genetics and enzymology of cell wall glycopolymer degradation and roles in cellular processes including cell division, morphogenesis and the expression of virulence properties.
- The enzymology, structural biology and associated bacterial physiology of lesser-known penicillin-binding proteins, and penicillin-binding protein variants associated with β-lactam resistance.
- The development of activity-independent in vitro platforms to interrogate the flux of xenobiotics across the bacterial cell envelope.

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Rebecca Shapiro

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To better study the biology and virulence of fungal pathogens, we are developing new genomic technology platforms for diverse fungal species. We are exploiting CRISPR-Cas9 based technologies to revolutionize the way we do high-throughput functional genomic analysis in fungal pathogens. This is enabling us to map large-scale genetic interaction networks, and uncover genetic factors and pathways that mediate important phenotypes associated with pathogenesis, antifungal drug resistance, and other biological processes associated with fungal infectious diseases.

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