- Department
- Email Address
- [email protected]
- Research Areas
- Research Keywords
- Research Description
Bacteria are encapsulated by a multi-layered envelope that protects the cell from the environment and performs vital functions crucial for survival. We study the biological chemistry underlying the biogenesis, homeostasis and remodelling of this complex bacterial structure, and apply the insights gained towards the development of antimicrobials that could be used to fight pathogenic bacteria.
- Research Summary
Our current research projects focus on:
- The genetics and enzymology of cell wall glycopolymer degradation and roles in cellular processes including cell division, morphogenesis and the expression of virulence properties.
- The enzymology, structural biology and associated bacterial physiology of lesser-known penicillin-binding proteins, and penicillin-binding protein variants associated with β-lactam resistance.
- Application of artificial intelligence to design to design novel inhibitors of privileged drug targets in bacteria.
- Techniques Used
In the Myers Lab, we employ a diverse array of approaches – protein biochemistry, biophysical chemistry, structural biology, molecular and functional genetics, microbial genetics, microscopy, synthetic biology, antimicrobial susceptibility testing, molecular modelling
- Locations of international collaborators
Venatorx Pharmaceuticals Inc., MTF Biologics, University of North Texas, Emory University School of Medicine (USA); University of Siena (Italy).
- Links
