- Email Address
- [email protected]
- Research Areas
- Research Keywords
- Research Description
The Shapiro lab studies infectious disease caused by microbial fungal pathogens. We use cutting-edge gene editing technologies, like CRISPR, to study the genetics, and mechanisms of disease and drug resistance of these pathogenic fungi.
- Research Summary
To better study the biology and virulence of fungal pathogens, we are developing new genomic technology platforms for diverse fungal species. We are exploiting CRISPR-Cas9 based technologies to revolutionize the way we do high-throughput functional genomic analysis in fungal pathogens. This is enabling us to map large-scale genetic interaction networks, and uncover genetic factors and pathways that mediate important phenotypes associated with pathogenesis, antifungal drug resistance, and other biological processes associated with fungal infectious diseases.
- Techniques Used
Functional genomics, microbial genetics, CRISPR gene editing, high-throughput screening, genetic screening, cloning, drug resistance testing, microscopy.
- Lab Equipment
PCR machines; plate readers (Abs, fluorescence); incubators to shake microtiter plates at high density; tissue culture; electronic multichannel pipettors.
- Locations of international collaborators
USA, Spain, Israel, China, UK.