John Vessey

Email Address
[email protected]
Research Description

I’m a neuroscientist who works on the fields of cellular, molecular, and developmental biology. My students and I are investigating various proteins that we think are important for RNA regulation during brain development.

Research Summary

Although my research could be described as cellular, molecular or developmental, at heart, I’m a neuroscientist spanning all of those categories. My research focuses on asymmetric RNA localization and localized translational control. In hippocampal neurons, this process serves to deliver specific mRNAs to distal dendrites where they wait for the proper signal to undergo translation where the resulting proteins subsequently contribute to synaptic plasticity. While learning about the genes and proteins involved in this process, I discovered that in organisms such as fruit flies and frogs, asymmetric RNA localization also plays a role in asymmetric cell divisions in the stem cells of the developing nervous system. I have also studied asymmetric RNA localization in neural stem cells and their contribution to both cellular differentiation and cortical development across species. Currently, my students and I are investigating various proteins that we think are important for RNA regulation during brain development.

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