- Email Address
- [email protected]
- Research Areas
- Research Keywords
- Research Description
My lab studies the way cells adhere to each other and migrate in multicellular organisms. These processes of adhesion and migration are important because if disrupted, they can lead to developmental disorders and contribute to the progression of arthritis, immunological deficiencies and cancer.
- Research Summary
Cell adhesion and migration are fundamentally important to the existence of multicellular organisms. This is obvious in light of the numerous diseases that can afflict humans when these processes are impaired. Disruption of normal cellular adhesive and migratory activities can lead to developmental disorders and contribute to the progression of arthritis, immunological deficiencies and cancer. Both cell adhesion and migration are complex processes involving numerous biochemical signalling events, reorganization of the cellular cytoskeleton and localized remodelling of the plasma membrane. It is the goal of my laboratory to elucidate the molecular mechanisms that link these activities, allowing them to be coordinated during changes in cell adhesion and motility.
- Locations of international collaborators
Massachusetts General Hospital (USA); VU University Medical Center, Netherlands Cancer Institute, Leiden University Medical Center, University Medical Centre Utrecht (Netherlands); Paris Sciences et Lettres Research University, Institut Curie (France).