Keyword: Antibiotic resistance

Jennifer Geddes-McAlister

We are interested in characterizing the mechanisms of pathogenesis, adaptation, and survival in fungal and bacterial microbes from a systems biology perspective through mass spectrometry-based quantitative proteomics. Specifically, research in the lab centres around the following areas:
1. Systems biology to elucidate microbial proteome dynamics and interactions;
2. Mechanistic characterization of pathogenic proteins; and
3. Mass spectrometry-based proteomics for drug discovery and repurposing.
Our long-term goals emphasize the utilization of mass spectrometry-based proteomics to fundamentally understand differential microbial adaptation and survival strategies and to integrate a novel systems biology platform for investigation of diverse biological systems.

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Georgina Cox

The Cox lab aims to gain a better understanding of the molecular underpinnings of resistance mechanisms. Specifically, we study bacterial efflux systems, which will provide insight into their physiological functions and origins and will also support future drug discovery efforts and antibiotic stewardship. In addition, recognizing the need for innovation in the search for new antibacterial agents, we are exploring novel approaches to control bacterial infections by investigating the inhibition of bacterial adhesion to host cells.

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