- Email Address
- [email protected]
- Research Description
My students and I work on nutrition. In particular, we look at: 1) the role of methyl nutrients in health outcomes and 2) the molecular mechanisms that underly the development of obesity, metabolic syndrome and chronic diseases. Our overarching goal is to contribute to evidence-based strategies that will improve the health of the population.
- Research Summary
The primary goals of our research program include: 1) to determine the fundamental role of methyl nutrients in health outcomes; 2) to determine molecular mechanisms underlying the development of obesity, metabolic syndrome and chronic diseases; and, 3) to contribute to evidence-based strategies that will improve the health of the population.
Previous research contributions extend to the following:
1) Role of maternal intake of methyl vitamins in development of energy regulatory pathways.
2) Plasticity of hypothalamic development of food intake regulatory pathways.
3) Impact of diet and gut microbiome on trimethylamine-N-oxide production and metabolic fate in humans.
4) Mode of delivery and development of the immune system in the offspring.
5) Functional food strategies to control blood glucose and food intake in humans.
- Techniques Used
Our research program utilizes animal models and human studies to answer questions from genetic, epigenetic, physiologic, metabolic and microbiome perspectives. Commonly used techniques include Western blotting, RT-PCR, DNA methylation assay, LC-MS/MS, ELISA, 16S rRNA sequencing, gross brain dissections and micro-dissections.