- Email Address
- [email protected]
- Research Areas
- Research Keywords
- Research Description
My lab studies signal transduction pathways, this is, the processes by which cells in the animal body exchange information within and with each other. We also focus on understanding how mutations (changes) in these transduction pathways can lead to human diseases, such as kidney disease and cancer.
- Research Summary
Research in our laboratory is focused on defining eukaryotic signal transduction pathways, and investigating how mutations in components of these pathways can contribute to human disease. Signal transduction is a central process in multicellular organisms that allows for the exchange of informational cues between and within cells. Current areas of research include: 1) Signalling pathways controlling kidney podocyte morphology; 2) focal adhesion dynamics in cancer cells; and, 3) characterization of a novel neuronal adaptor protein, ShcD.
- Techniques Used
Our research team utilizes an interdisciplinary approach, which includes modern mouse genetic tools, cell culture models, high-resolution microscopy, large-scale profiling techniques and clinical specimens.
- Locations of international collaborators
Massachusetts General Hospital, Northwestern University of Chicago (USA); Oslo University Hospital (Norway); Universidade Federal do Rio Grande do Norte (Brazil).