- Email Address
- [email protected]
- Research Areas
- Research Keywords
- Research Description
My lab has two main lines of research. One focuses on proteins that play key roles in animal stress responses, and that are linked to diseases such as Alzheimer’s, diabetes, cancer, and viral infection. The other one focuses on the molecular mechanisms of aging and their association with stress.
- Research Summary
My lab focuses on two main axes of research:
1) Unfolded Protein Response and Human Diseases: We study proteins that play key roles in animal stress responses, specifically the Unfolded Protein Response (UPR), which has been linked to animal development, cell differentiation, as well as a variety of human diseases such as Alzheimer’s, diabetes, cancer and viral infection.
2) Molecular Mechanisms of Aging: We are working to establish planarians as a new aging model to test the hypothesis that longevity requires multiplex resistance to stress. We hope to identify genes or alleles that confer such multiplex stress resistance and/or promote longevity.
- Techniques Used
We use gene knockout mouse models, combined with molecular and cellular biology techniques.
- Locations of international collaborators
University of Pittsburgh, Brown University School of Public Health, Yale School of Public Health, Vanderbilt University (USA); Qingdao Agricultural University (China).