Using various omics technologies, my research program seeks to understand how genetic variation influences differing responses to nutrition and how this in turn impacts health outcomes. My research also focuses on translational genomics, and seeks to identify how to best integrate nutritional genomics into clinical practice. In addition, my lab focuses on evaluating potential metabolic and health impacts among carriers of inborn errors of metabolism.
Learn MoreMy students and I aim to understand the mechanistic role(s) of microbial-host intestinal communication. In particular, we focus on how microbial-derived metabolites (from dietary precursors) can influence the integrity of the colonic epithelial barrier (EB), as well as its capacity for defense and repair. The importance of this research lies on not only advancing basic knowledge on the effect of microbial metabolites on gastrointestinal functions, but also on informing the agri-food sector the ways in which the intake of nutrients, biomolecules, and dietary precursors can shape human health.
Learn MoreCurrently, there are several major areas of research focus including the study of basic fatty acid metabolism, understanding the association between plasma fatty acids and health outcomes, omega-3 fatty acids in the prevention of breast cancer, and examining determinants of health in the Guelph Family Health Study. In addition, related projects include the study of fats in brain health (concussion, Alzheimer's Disease), fatty liver disease, fatty acid metabolism, bone development and nutrigenomics.
Learn MoreDysfunctional lipid metabolism is a key feature of cardiometabolic diseases, such as obesity and type 2 diabetes. My research program has three primary areas of interest:
First, we are using cell and mouse models to determine how omega-3 fats regulate lipid metabolism. We are investigating how omega-3 fats control adipogenesis, as well as lipogenic, lipolytic, and triglyceride synthesis pathways in adipose tissue and liver.
Second, we are studying how different nutrients regulate omega-3 synthesis in the body using both mouse models and human clinical trials.
Third, we are interested to personalize nutrition to improve human cardiometabolic health. We continue to be active in this area through various national and international collaborations.
