David Mutch

Email Address
[email protected]
Research Areas
Research Keywords
Research Description

My nutrigenomics laboratory is focused on understanding how fatty acids influence cardiometabolic health. We use cell models, rodents, and human clinical trials to study how different fatty acids interact with genes to regulate adipose tissue, skeletal muscle, and liver function. We are interested to use the knowledge generated by these studies to provide a foundation for personalized nutrition.

Research Summary

Dysfunctional lipid metabolism is a key feature of cardiometabolic diseases, such as obesity and type 2 diabetes. My research program has three primary areas of interest:
First, we are using cell and mouse models to determine how omega-3 fats regulate lipid metabolism. We are investigating how omega-3 fats control adipogenesis, as well as lipogenic, lipolytic, and triglyceride synthesis pathways in adipose tissue and liver.
Second, we are studying how different nutrients regulate omega-3 synthesis in the body using both mouse models and human clinical trials.
Third, we are interested to personalize nutrition to improve human cardiometabolic health. We continue to be active in this area through various national and international collaborations.

Techniques Used

Cell culture; genetic mouse models; gas chromatography; gene expression; bioinformatics; human clinical trials; genotyping; metabolomics.

Lab Equipment

Affymetrix GeneAtlas, IKA Bomb Calorimeter, BioRad CFX-96.

Locations of international collaborators

Clermont-Ferrand (France); Tel-Aviv (Israel); Illinois (USA).

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