- Email Address
- [email protected]
- Research Areas
- Research Keywords
- Research Description
Dr. Todd Gillis' lab is focused on the vertebrate heart and the mechanisms that regulate it’s function and ability to remodel in response to a physiological stressor.
- Research Summary
Ongoing projects include:
1) Examining cardiac remodeling in zebrafish and trout in response to thermal acclimation.
2) Characterizing the role of the troponin complex in regulating the function of striated muscle.
3) Examining the function of the hagfish heart during prolonged anoxia exposure.
4) Examining the change in diaphragm function during the onset of heart failure.
5) Characterizing how bitumen exposure of sockeye salmon early life stages influences cardiac development and aerobic fitness.
- Techniques Used
Western blotting, SDS PAGE, quantitative PCR, cardiac ultrasound, isolated functional heart preparation, tissue histology, live animal respirometry, tissue culture, enzyme kinetics, recombinant protein expression, site directed mutagenesis, muscle biophysics, stopped flow kinetic analysis, tissue proteomics using MS approaches.
- Lab Equipment
Western blotting rig, ChemiDoc imager, Fuji cardiac ultrasound, Precellys tissue homogenizer, FPLC, Aurora muscle mechanics rig, stopped flow kinetic analyzer, Perkin Elmer spectroflurometer, FlexCell cell stretcher, tissue culture incubator.