While animal models have lead to huge advancements in our understanding of neurobiology, there is controversy over whether overexpression/silencing of gene expression is representative of diverse disease states. Indeed, the lack of availability of primary human neurons has made evaluating the pathological consequences of genomic mutations arduous. The use of human induced pluripotent stem cell (hiPSC) technology overcomes these limitations by providing a source of human neurons from both normal and disease genetic backgrounds. We currently focus on stem cell based models of Parkinson's Disease (PD) to study how mitochondrial stress mechanisms impact on neuronal function in human disease.Learn More
Research Area: Environmental health
Molecular biodiversity research and highly qualified personnel training are lab focal points. Using field and lab-based methods together with bioinformatic tools and statistical modelling approaches, we study the patterns and drivers of species habitat occupancy, community assembly and food web ecology. This information is central to addressing a variety of questions pertaining to biodiversity conservation, environmental effects monitoring and food security. We also contribute to the development of standard methods and best practices necessary to enhance receptor uptake capacity for a variety of partners including indigenous peoples, industry, governmental as well as non-governmental organizations, and other citizen science initiatives.Learn More
Current projects include:
- Mechanistic and functional connections between stress and adult neurogenesis in fish
- Effects of aquatic pollutants on fish physiology, morphology, and performance
- Neuroanatomy and regenerative capacity of the hagfish brain
- Quantitative proteomics as a tool for biomarker discovery and novel insights into animal physiology
Dr. Heyland�s laboratory uses novel functional genomics approaches to study the endocrine and neuroendocrine systems of aquatic invertebrates. Specifically he investigates the function and evolution of hormonal and neurotransmitter signaling systems in the regulation of development and metamorphosis. His research includes Evolutionary development studies of marine invertebrate metamorphosis, eco-toxicogenomic approached to understand endocrine disruption in aquatic ecosystems and water remediation technologies. These projects are integrated with several national and international collaborations ranging form basic scientific work to industry partnerships.Learn More
My research focuses on the reproductive physiology of fish. We study which hormones affect ovarian follicle development and if there are hallmark responses (changes in hormone biosynthesis, receptor abundance, recruitment of downstream activators) that determine whether an ovarian follicle is destined to mature and ovulate. This research is fundamental to defining spawning success which is a prime measure of reproductive fitness and provides the toolbox that we use to examine the mechanisms by which endocrine disrupting compounds (pharmaceuticals; ammonia) and complex environmental effluents (municipal waste water, pulp mills; oils sands process affected water) affect ovarian physiology.Learn More
We are interested in microbial enzymes involved in the steroid and aromatic compounds degradation. These enzymes are important for bioremediation of organic pollutants and are potential targets for development of antibiotics against tuberculosis. In collaboration with Dr. Ting Zhou at Agriculture Agri-food Canada, we are isolating and characterizing enzymes capable of detoxifying the mycotoxins, deoxynivalenol and patulin. These mycotoxins contaminate grains and fruit juices.Learn More
In eastern Canada, the lumpfish and a North American wrasse, the cunner, significantly reduce adult lice densities on salmon living in marine sea cages. My group's work has the following objectives: 1) determine the best size-class of cunners to use in commercial sea cages; 2) examine variation in lice-cleaning performance among cunners and among lumpfish from different stocks; 3) assess heritable variation in lice eating behaviour; 4) Conduct lice challenges of pedigreed salmon with and without the lice cleaner fish present.
3) Increased sea surface temperatures have allowed larval shore crab to invade western Canadian shores and prey on indigenous snail species. We are identifying genomic changes correlated with adaptation to predators in a 25 year field experiment near Bamfield, BC.