Department: Department of Molecular and Cellular Biology

Angela Scott

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Overall, my research program takes an integrative and comparative approach to study glial-neuronal interactions in relation to early development, physical injury, and neurological disease that spans across multiple levels of biological organization (molecular and cellular physiology > systems biology) and multiple model species (zebrafish and mice).
Our two areas of focus are:
1) investigation of glial-mediated mechanisms underlying development and disease;
2) exploration of naturally adaptive models with significant recovery from, or tolerance to, neurological stress or disease.

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Robert Harkness

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The Harkness group studies the dynamics of biological molecules toward better understanding how these influence human health and disease. Broadly, our areas of interest include:
(1) How biological macromolecules self-assemble, for example oligomeric protein “machines” that perform reactions as required by the cell, or non-canonical nucleic acid structures such as G-quadruplexes that regulate gene expression.
(2) The mechanisms of biomolecular recognition, e.g. allostery in modulation of the interactions between proteins and ligands.
(3) The relationship between structural dynamics and biological activity.

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Cullen Myers

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Our current research projects focus on:
- The genetics and enzymology of cell wall glycopolymer degradation and roles in cellular processes including cell division, morphogenesis and the expression of virulence properties.
- The enzymology, structural biology and associated bacterial physiology of lesser-known penicillin-binding proteins, and penicillin-binding protein variants associated with β-lactam resistance.
- The development of activity-independent in vitro platforms to interrogate the flux of xenobiotics across the bacterial cell envelope.

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Priyanka Pundir

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We study how eukaryotic cells communicate with microorganisms, focusing on cell surface receptors and their interaction with host and microbe ligands. We work at the intersection of immunology, microbiology, and neurobiology on how G protein-coupled receptors (GPCRs) on mast cells detect interbacterial communication and trigger antibacterial immune defense. We have shown that GPCRs can detect bacterial quorum sensing molecules, which are used by bacteria to coordinate group behaviors like forming biofilms and developing antibiotic resistance. When mast cells detect these signals, they release anti-bacterial mediators that attract other immune cells to sites of infection. Our ultimate goal is to advance knowledge that can lead to new treatments for infectious and inflammatory diseases.

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Melanie Alpaugh

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The Alpaugh Lab studies the mechanisms and consequences of protein misfolding in neurodegenerative diseases.
Theme 1- Interactions between the blood-brain barrier and misfolded proteins. Protein accumulation and blood-brain barrier break down are common features of diseases such as Alzheimer’s, Parkinson’s and Huntington’s diseases. We aim to understand if these two common disease features are related using a human 3D-cell culture model of the blood-brain barrier and human tissue.
Theme 2- Contributions of huntingtin seeding and spreading to Huntington’s disease. The mutant huntingtin protein displays prion-like properties. The Alpaugh lab is tackling the relevance to Huntington’s disease using tissue from human patients with Huntington’s disease phenocopies and Huntington’s disease.

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Yang Xu

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Research in the Xu laboratory focuses on plant and microalgal lipid metabolism. By applying state-of-the-art approaches in genetics, biochemistry, cellular biology, synthetic biology and biotechnology, we aim to address both fundamental and applied questions in the field. The major research objectives in our research group are to improve our understanding of the mechanisms underlying acyl lipid assembly (e.g. triacylglycerols/oils, galactolipids/photosynthetic membrane lipids, phospholipids/membrane lipids) in photosynthetic organisms and to design lipid biosynthetic pathways to improve agriculture production and produce value-added oils for food, feed, fuel, and materials applications.

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Matthew Sorbara

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Healthy gut microbiota can be disrupted due to antibiotic treatment, intestinal inflammation, or changes in diet. Targeted restoration of the microbiota will require an understanding of how genomic diversity between closely related microbes influences their ability to drive beneficial functions. To address this, our laboratory will use a large collection of whole-genome sequenced isolates to understand how variation between closely related gut isolates alters their ability to prevent pathogen expansion and maintain homeostatic interactions with the mucosal immune system.

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John Vessey

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My research focuses on asymmetric RNA localization and localized translational control in animal species. I have also studied asymmetric RNA localization in neural stem cells and their contribution to both cellular differentiation and cortical development across species. Currently, my students and I are investigating various proteins that we think are important for RNA regulation during brain development.

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Baozhong Meng

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The ultimate goal of my research is to understand viruses and viral diseases for the betterment of agriculture. Our research involves a number of important viruses that infect plants, which include Grapevine rupestris stem pitting-associated virus (GRSPaV), a ubiquitous and important pathogen of grapes worldwide. Current research directions include: Processing and subcellular localization of polyproteins; structure and cellular localization of viral replication complexes; evolution and bio-informatics of grapevine viruses; development of virus-induced gene-silencing vectors ; and, development and application of technologies for the diagnosis of grapevine viruses.

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Siavash Vahidi

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A key focus of the group is on the protein degradation machinery that helps to maintain proper level of proteins (protein homeostasis) in Mycobacterium tuberculosis, the causative agent of TB, the world's single largest infectious killer that is annually responsible for 1.5 million deaths. The questions we aim to answer are:
1) What is the assembly mechanism of the M. tuberculosis proteasome core particle and its regulatory particles?
2) What is the role of allostery and long-range interactions in the machinery that tags substrates for proteasomal degradation?
3) How are substrates selected for tagging and degradation?
4) What is the molecular basis of antibiotics that operate by disrupting proteasomal protein degradation?

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George van der Merwe

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We study the transcriptomic and proteomic adaptation of yeasts to changing nutrient environments, as well as their domestication and fermentation to better understand yeast performance and potentially develop strategies and predictions of fermentation efficiencies and flavour compound production during alcoholic fermentations. We also look at yeast diversity and the unique flavour compounds that could expand product diversity in the wine, beer and cider industries.

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Terry Van Raay

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Many of the signaling pathways that are involved in development are also involved in the onset and progression of disease. As an example, the Wnt signaling pathway is required during many stages of development and in the homeostasis of stem cells in the adult. Perturbation of this pathway in stem cells in the adult often leads to cancer. It is now known that greater than 90% of colorectal cancers are caused by mutations in the Wnt signaling pathway. As this pathway is important for both proper development and disease, I am curious to know how this pathway can turn it self on and off so many times during development and why it fails to turn off in disease. The lab focuses on two negative feedback regulators of Wnt signaling: Nkd1 and Axin2.

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Melanie Wills

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My research group focuses on the diagnosis, prognosis and treatment of Lyme disease. I focus on different topics within this research theme, including: 1) the various forms that Borrelia (Lyme bacteria) can adopt and their corresponding role in the expression of the disease; 2) the effects of people and bacteria genetics in the expression of of the disease; 3) the development of new diagnostic tools; and, 4) the interactions that people diagnosed with Lyme disease have with the medical system.

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Robert Mullen

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My research focuses on three main areas of plant cell biology:
1) Characterization of enzymes involved in seed oil biosynthesis.
2) Understanding various aspects of the biogenesis of peroxisomes, including how membrane proteins are targeted to this organelle, and what role the endoplasmic reticulum (ER) serves in the formation of peroxisomes.
3) Identification and characterization of a unique class of integral membrane proteins known as "Tail-Anchored" (TA) proteins.

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Jaideep Mathur

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Our lab works on three major areas of plant biology:
1) Cytoskeleton & Cell Morphogenesis: We study the pivotal role played by the cytoskeleton in cell shape development in higher plants.
2) Live Cell Visualization & Organelle Dynamics: We dissect the response hierarchy and localized co-operation between plastids, mitochondria and peroxisomes and also between the actin and microtubule components of the cytoskeleton during differential growth in higher plant cells.
3) Plant Interactions: We document the earliest intracellular responses of plant cells to diverse environmental stimuli.

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Ray Lu

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My lab focuses on two main axes of research:
1) Unfolded Protein Response and Human Diseases: We study proteins that play key roles in animal stress responses, specifically the Unfolded Protein Response (UPR), which has been linked to animal development, cell differentiation, as well as a variety of human diseases such as Alzheimer’s, diabetes, cancer and viral infection.
2) Molecular Mechanisms of Aging: We are working to establish planarians as a new aging model to test the hypothesis that longevity requires multiplex resistance to stress. We hope to identify genes or alleles that confer such multiplex stress resistance and/or promote longevity.

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Michael Emes

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Much of our current effort is focused on understanding the regulation of starch synthesis in storage tissues such as the developing seeds of cereals. Starch is the major determinant of yield in such crops, and has wide application in both the food and non-food industries, yet there remain a huge number of unknowns in what limits the production and structure of this important glucan polymer. There is also an increasing realization that different types of starch provide benefits for human health. Our research covers cereals such as maize, barley, rice, and wheat, as well as the model organism Arabidopsis thaliana. I lead a large, interdisciplinary team whose expertise includes plant biochemistry, genetics, molecular biology, microbiology, human physiology, and nutrition.

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Nina Jones

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Research in our laboratory is focused on defining eukaryotic signal transduction pathways, and investigating how mutations in components of these pathways can contribute to human disease. Signal transduction is a central process in multicellular organisms that allows for the exchange of informational cues between and within cells. Current areas of research include: 1) Signalling pathways controlling kidney podocyte morphology; 2) focal adhesion dynamics in cancer cells; and, 3) characterization of a novel neuronal adaptor protein, ShcD.

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Marc Coppolino

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Cell adhesion and migration are fundamentally important to the existence of multicellular organisms. This is obvious in light of the numerous diseases that can afflict humans when these processes are impaired. Disruption of normal cellular adhesive and migratory activities can lead to developmental disorders and contribute to the progression of arthritis, immunological deficiencies and cancer. Both cell adhesion and migration are complex processes involving numerous biochemical signalling events, reorganization of the cellular cytoskeleton and localized remodelling of the plasma membrane. It is the goal of my laboratory to elucidate the molecular mechanisms that link these activities, allowing them to be coordinated during changes in cell adhesion and motility.

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Joseph Colasanti

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One of the fundamental questions in plant biology concerns the nature of the signals that bring about the transition from vegetative to reproductive growth. My research is aimed at characterizing the developmental signals that cause plants to flower. The primary focus of this work is the maize indeterminate gene (id1). Maize plants that lack id1 function flower extremely late, or not at all, and they exhibit abnormal flower development. The ID1 protein contains zinc-finger motifs, suggesting that it regulates the expression of other genes. Expression analysis reveals that id1 mRNA is expressed only in leaf tissue, suggesting that ID1 acts by controlling the production of leaf-derived signals that mediate the transition to flowering.

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Mark Baker

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My lab aims to understand 1) the molecular genetic mechanisms of recombination in mammalian cells; 2) how defects in recombination contribute to tumorigenesis; and, 3) the nature of recombination hotspots. We are presently researching questions pertaining to: the mechanism and frequency of recombination in mammalian cells; the role of large palindromes in promoting recombination; mammalian heteroduplex DNA formation and repair; genetics of strand invasion and 3' end polymerization; how DNA sequences act to stimulate recombination; non-crossover mechanisms of homologous recombination; the genetic control of recombination.

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Tariq Akhtar

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My primary research interest concerns the splendid array of compounds that are made by plants and the underlying molecular and biochemical basis of their synthesis. My lab focuses on natural products that are of medicinal, industrial or pharmacological relevance and on specialized metabolites that help plants cope with their dynamic environment. As an example, we investigate the biosynthesis, composition and structure of plant-derived polyisoprenoids. We also work closely with collaborators in various fields such as organic chemistry, food science, neurobiology, and ecology with the overall goal to shed light on the processes that operate at the interface of plant primary and secondary metabolism.

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Shaun Sanders

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The Sanders lab is interested in how neurons use the protein-lipid modification palmitoylation to target proteins to subcellular locations and to define how palmitoylation-dependent targeting contributes to physiological neuronal function and neuropathological conditions. Current projects include characterizing how palmitoylation of vesicular transport machinery regulates fast axonal transport and how palmitoylation of ion channels and their scaffold proteins regulates clustering at the axon initial segment, a critical site of neuronal excitability where action potentials are generated.

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Ian Tetlow

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My lab examines the control mechanisms underpinning starch biosynthesis in leaf chloroplasts (which make starch during the daytime, and degrade it at night) of the model plant Arabidopsis thaliana, and non-photosynthetic amyloplasts of cereal endosperms such as maize, wheat, barley and rice which make storage starches. More specifically, we are interested in the biochemical control mechanisms governing the many enzymes and enzyme classes which make up the core pathway of starch biosynthesis. This involves investigating the role of protein-protein interactions and protein phosphorylation in coordinating the proteins involved in starch synthesis and degradation within the plastid to produce the highly ordered and complex structure of the starch granule.

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