We are interested in understanding complicated genetic networks in fungal pathogens. Focusing primarily on the common yeast pathogen Candida albicans and the emerging pathogen Candida auris, our lab is developing and optimizing novel CRISPR based functional genomic technologies and using them to modulate the fungal genome on a large scale. We are applying these technologies for large-scale functional genomic screening, in order to understand the genes and genetic interactions that underly fungal pathogenesis (including cellular morphogenesis and biofilm formation), the evolution of antifungal drug resistance.Learn More
My research program investigates the ecological and evolutionary processes operating in plant populations, both wild and domesticated. Much of our work is conducted through the lens of plant reproductive systems, which control the quantity and quality of sperm and eggs, patterns of mating, and ultimately the transmission of genetic variation from one generation to the next. Current research projects include: 1) mating system variation and evolution, 2) polyploid speciation, 3) genetic and phenotypic consequences of whole genome duplication; 4) biology of small populations, and 5) impacts of hybridization between introduced species and endangered congeners. We work on a variety of study systems, including Arabidopsis, apple, strawberry, fireweed, American chestnut, and mulberry.Learn More
More than 4 million Canadians have arthritis and the number of people living with arthritis continues to increase year after year. Osteoarthritis involves multiple tissues and often includes cartilage damage, bone sclerosis and synovial inflammation. A pressing need remains for joint localized therapies and interventions that could slow or ideally stop this debilitating disease.
In our research, we use genetic and surgical models of spontaneous osteoarthritis (with old age) and post-traumatic osteoarthritis (following injury). We follow the progression of disease in a joint in order to better understand how proteins such as TRPV4, integrin alpha1beta1 and cilia influence chondrocyte signal transduction and thus the development of osteoarthritis.
Currently, there are several major areas of research focus including the study of basic fatty acid metabolism, understanding the association between plasma fatty acids and health outcomes, omega-3 fatty acids in the prevention of breast cancer, and examining determinants of health in the Guelph Family Health Study. In addition, related projects include the study of fats in brain health (concussion, Alzheimer's Disease), fatty liver disease, fatty acid metabolism, bone development and nutrigenomics.Learn More
Dr. Heyland�s laboratory uses novel functional genomics approaches to study the endocrine and neuroendocrine systems of aquatic invertebrates. Specifically he investigates the function and evolution of hormonal and neurotransmitter signaling systems in the regulation of development and metamorphosis. His research includes Evolutionary development studies of marine invertebrate metamorphosis, eco-toxicogenomic approached to understand endocrine disruption in aquatic ecosystems and water remediation technologies. These projects are integrated with several national and international collaborations ranging form basic scientific work to industry partnerships.Learn More
My research focuses on the reproductive physiology of fish. We study which hormones affect ovarian follicle development and if there are hallmark responses (changes in hormone biosynthesis, receptor abundance, recruitment of downstream activators) that determine whether an ovarian follicle is destined to mature and ovulate. This research is fundamental to defining spawning success which is a prime measure of reproductive fitness and provides the toolbox that we use to examine the mechanisms by which endocrine disrupting compounds (pharmaceuticals; ammonia) and complex environmental effluents (municipal waste water, pulp mills; oils sands process affected water) affect ovarian physiology.Learn More
A current focus of our coalescent-based work is the development of models to support inferring historical processes that shape an ecological community, from genes to ecosystem processes. These models have applications across the domains of life, from microbial communities to grasslands. A corollary to this work is theory in support of the interpretation of metagenomic data. In the area of polyploid population genetics, our work is currently focusing on models of multilocus selection, with potential application to understanding the evolution of recombination rates and diploidization.Learn More
Research in the Crease lab uses freshwater crustaceans in the genus Daphnia as a model organism to study evolution of the ribosomal (r)DNA multigene family, and of the DNA transposon, Pokey, which inserts in a specific region of the Daphnia rDNA repeat as well as other genomic locations. Current projects involve comparing rates of evolution in ribosomal proteins that bind to conserved and variable regions of rRNA genes, determining the impact of breeding system (cyclic or obligate parthenogenesis) on the evolution of rDNA and Pokey transposons, determining the relationship between rDNA copy number and Pokey distribution, and measuring rates of Pokey transposition inside and outside of rDNA.Learn More
My interest in clinical biomechanics and neurophysiology evolved during my years as a primary health care provider in chiropractic and acupuncture. Over two decades of clinical observation underscored the fact that these, and other commonly adopted conservative clinical therapies/interventions, have a profound impact on human physiology, the scope and mechanisms of which are still poorly characterized. I began private practice in 1992 where I quickly developed a fascination for the clinical enigma of chronic musculoskeletal pain, the most common form of which being chronic myofascial pain.
My research program adopts a broad and integrative approach to the study of chronic musculoskeletal pain, incorporating both basic and clinical sciences. A major arm to my research program is investigatLearn More
Skeletal muscle is a remarkable tissue which regulates many metabolic processes, generates heat and is the basic motor of locomotion allowing us to meaningfully interact with our environment. When a muscle is activated at various lengths it produces a given predictable amount of force. However, when that muscle is actively lengthened or shortened those predictions go out the window. We actually know very little regarding dynamic muscle contraction. My research program focuses on muscle contractile properties and gaining a deeper understanding of how muscle works. I use altered states to tease out some of these fine muscle details such as: Muscle fatigue, Aging, And Training.Learn More
Protein synthesis involves the translation of ribonucleic acid information into proteins, the building blocks of life. The initial step of protein synthesis consists of the eukaryotic translation initiation factor 4E (eIF4E) binding to the 5� cap of mRNAs. However, many cellular stresses repress cap-dependent translation to conserve energy by sequestering eIF4E. This raises a fundamental question in biology as to how proteins are synthesized during periods of cellular stress and eIF4E inhibition. Research in our laboratory will build upon the discovery that cells switch to an alternative cap-binding protein, eIF4E2, to synthesize the bulk of their proteins during periods of oxygen scarcity (hypoxia).Learn More
Our research centres on the application of physical activity and other acute/chronic perturbations to human physiology to understand how and why the body adapts to these stresses. We take an integrative systems approach, with our work focusing on interventions and assessments of cardiovascular, respiratory and muscular physiology. Specific focus areas include projects to understand the effects peripheral blood flow manipulation, the consequences of particularly stressful exercise, and novel training methods to optimize targetted physiological adaptations. From a health perspective, we are interested in understanding how exercise can be used to prevent and control risk factors for cardiovascular and cardiometabolic disease.Learn More