My research focuses on asymmetric RNA localization and localized translational control in animal species. I have also studied asymmetric RNA localization in neural stem cells and their contribution to both cellular differentiation and cortical development across species. Currently, my students and I are investigating various proteins that we think are important for RNA regulation during brain development.Learn More
We study the transcriptomic and proteomic adaptation of yeasts to changing nutrient environments, as well as their domestication and fermentation to better understand yeast performance and potentially develop strategies and predictions of fermentation efficiencies and flavour compound production during alcoholic fermentations. We also look at yeast diversity and the unique flavour compounds that could expand product diversity in the wine, beer and cider industries.Learn More
My research group investigates biotic and abiotic stress on plants at the cellular and sub-cellular biochemical and molecular levels. The objective is to identify what changes occur in plant cells upon exposure to stress and which of these changes aid the plant to increase its tolerance to the stress.A major focus currently is the investigation of freezing stress tolerance in grapevines. Winters in Ontario can cause substantial damage to the cultivated grapes used in the Wine Industry, whereas wild grapes have no problems. We try to find out what the molecular basis is for this phenomenon. The ultimate goal is to use this knowledge to improve freezing and drought stress tolerance in the cultivated grapes.Learn More
My research group focuses on the diagnosis, prognosis and treatment of Lyme disease. I focus on different topics within this research theme, including: 1) the various forms that Borrelia (Lyme bacteria) can adopt and their corresponding role in the expression of the disease; 2) the effects of people and bacteria genetics in the expression of of the disease; 3) the development of new diagnostic tools; and, 4) the interactions that people diagnosed with Lyme disease have with the medical system.Learn More
The primary goals of my research program are 1) to understand where posture is controlled 2) to understand what sensory information contributes to successful movement and equilibrium.
By investigating these two key questions I believe we will have a better understanding of how sensory decline contributes to a loss of mobility as we age. My research program involves two key areas of study:
1) To perform direct recordings from sensory afferents and motor efferents in awake human subjects to investigate sensory contributions to movement, balance control, and reflex responses.
2) To elicit balance perturbations to test the function of these reflex loops, and sensory contributions to the maintenance of equilibrium and postural control.
My interests lie in the regulation of fat and carbohydrate metabolism in skeletal muscle, with a particular emphasis on the dysregulation that occurs in obesity and diabetes. Several cytokines released from skeletal muscle, including leptin and adiponectin, are known to significantly affect insulin response in peripheral tissues such as muscle. My research has focused on the effects of these adipokines on muscle lipid and carbohydrate metabolism, and particularly, how the muscle becomes resistant to their effects in obese models and with high fat feeding. The interaction of diet and exercise is also a point of interest in terms of the muscle's response to various hormones including insulin, leptin and adiponectin.Learn More
The ultimate goal of my research is to understand viruses and viral diseases for the betterment of agriculture. Our research involves a number of important viruses that infect plants, which include Grapevine rupestris stem pitting-associated virus (GRSPaV), a ubiquitous and important pathogen of grapes worldwide. Current research directions include: Processing and subcellular localization of polyproteins; structure and cellular localization of viral replication complexes; evolution and bio-informatics of grapevine viruses; development of virus-induced gene-silencing vectors ; and, development and application of technologies for the diagnosis of grapevine viruses.Learn More
A key focus of the group is on the protein degradation machinery that helps to maintain proper level of proteins (protein homeostasis) in Mycobacterium tuberculosis, the causative agent of TB, the world's single largest infectious killer that is annually responsible for 1.5 million deaths. The questions we aim to answer are:
1) What is the assembly mechanism of the M. tuberculosis proteasome core particle and its regulatory particles?
2) What is the role of allostery and long-range interactions in the machinery that tags substrates for proteasomal degradation?
3) How are substrates selected for tagging and degradation?
4) What is the molecular basis of antibiotics that operate by disrupting proteasomal protein degradation?
My research program spans three themes:
1) Great Lakes Fish Ecology: This includes developmental biology, animal behaviour, fish habitat, effect of exotic species, species-at-risk, fish population and community dynamics, and the response of ecosystems to disturbance.
2) Science in Natural Resource Management: I focus on Indigenous resource management negotiations with Canada, Ontario, as well as Industry and Environmental NGOs.
3) Indigenous-Western Science Knowledge Systems: I critically examine the theoretical and practical basis for engagement between traditional knowledge holders and 'Western' scientists/managers.
The ecological and evolutionary problems that underlie my research interests include the convergent evolution of morphology, the manner by which organisms have adapted to their physical environment, physical aspects of energy transfer through ecosystems, and physical-biological linkages in aquatic systems. My lab is currently examining the physical ecology of trophic interactions, reproduction (including abiotic pollination and broadcast spawning), physical-biological interactions and larval recruitment, limnological processes involving hypoxia, hydrological processes involving benthic organisms, and sediment/substrate-water interactions.Learn More
My work spans five major axes of research:
1) The shape of the Tree of Life, including the relationships amongst species and the factors that influence the shape of this tree.
2) Major transitions in evolution, especially the frequency of transitions, the rate at which reversals occur, and the consequences of such transitions for molecular evolutionary patterns and speciation rates.
3) Evolutionary trends, with a focus on whether there are large-scale patterns in the history of life.
4) The diversity and integrity of freshwater ecosystems, including the diversity, distributions, traits, and origins of species.
5) The diversity of polar life, which I study using DNA barcoding to discover the true extent of arctic species diversity.
Our research is focused on identifying and understanding the pathways by which environmental and social stressors are perceived, processed, and transduced into a neuroendocrine response. Several projects are aimed at elucidating how the neuroendocrine system orchestrates the stress response and focused specifically on the physiological functions of the corticotropin-releasing factor (CRF) system. Another major focus of the lab is to investigate the interactions between the neuroendocrine pathways that regulate the stress response and those involved in the regulation of appetite and growth.Learn More
My research explores biodiversity from different perspectives and scales. We have develop molecular diagnostic tools for plant identification, including herbal product authentication and certification. Also, we contribute to the Plant Barcode of Life, investigating intra and interspecific variation in plants, and incorporate both Indigenous knowledge and DNA-based approaches to understanding diversity. In addition, I have extensively researched the effects of ecosystem management on community structure. Lastly, I am engaged in the scholarship of teaching and learning and have recently looked at 1) learning objects as mechanisms of engagement, 2) active learning within large first year biology classes, and 3) ancient pedagogies.Learn More
My research focuses on three main areas of plant cell biology:
1) Characterization of enzymes involved in seed oil biosynthesis.
2) Understanding various aspects of the biogenesis of peroxisomes, including how membrane proteins are targeted to this organelle, and what role the endoplasmic reticulum (ER) serves in the formation of peroxisomes.
3) Identification and characterization of a unique class of integral membrane proteins known as "Tail-Anchored" (TA) proteins.
My research is in the general area of protein structure and dynamics and is specifically focused on the biochemistry of bacterial toxins involved in disease and consists of the following projects: Membrane structure of the colicin E1 ion channel; data mining and bioinformatics of bacterial virulence factors; optical spectroscopic approaches to study protein structure and dynamics; enzyme reaction mechanism of the bacterial mono-ADP-ribosyltransferase family; inhibition mechanisms and structural complexes of toxins with inhibitors; and, X-ray structures of protein-protein complexes involving toxins.Learn More
My lab focuses on two main axes of research:
1) Unfolded Protein Response and Human Diseases: We study proteins that play key roles in animal stress responses, specifically the Unfolded Protein Response (UPR), which has been linked to animal development, cell differentiation, as well as a variety of human diseases such as Alzheimer’s, diabetes, cancer and viral infection.
2) Molecular Mechanisms of Aging: We are working to establish planarians as a new aging model to test the hypothesis that longevity requires multiplex resistance to stress. We hope to identify genes or alleles that confer such multiplex stress resistance and/or promote longevity.
Our lab works on three major areas of plant biology:
1) Cytoskeleton & Cell Morphogenesis: We study the pivotal role played by the cytoskeleton in cell shape development in higher plants.
2) Live Cell Visualization & Organelle Dynamics: We dissect the response hierarchy and localized co-operation between plastids, mitochondria and peroxisomes and also between the actin and microtubule components of the cytoskeleton during differential growth in higher plant cells.
3) Plant Interactions: We document the earliest intracellular responses of plant cells to diverse environmental stimuli.
We study the evolution of plant function and its mechanistic links to the ecological functioning of populations, communities and ecosystems. We study how and why plant functional traits evolve, and how these traits influence the outcome of ecological interactions that are known to shape community assembly, such as competition and mutualism. To do this work, we use several approaches, including comparative analyses among populations and species, observations of natural selection in the wild, and experimental studies that manipulate the identity of selective agents experienced by populations. We explore how traits influence community assembly and ecosystem function by carrying out experimental studies in controlled environments and in the field.Learn More
I study evolution in heterogeneous environments, over large geographic ranges, and in the presence of variable species assemblages by using computational approaches and bioinformatics techniques to analyze large, high-resolution genomic datasets. My work revolves around two focal questions: 1) How consistent are evolutionary and ecological outcomes of species interactions? and 2) To what extent are species evolutionarily cohesive across their ranges? Most of the fish species I study are affected by human-mediated disturbances, including species introductions and fragmentation of aquatic habitat by dams. I use large genomic, ecological, and isotopic datasets to understand how evolutionary processes function across ecological contexts.Learn More
I conduct research along three axes:
1) Education: Our research program is designed to serve at the leading edge of scholarship in experiential and transdisciplinary education. It is driven by the existing evidence base in pedagogical best practice, in partnership with community need.
2) Biomimetics: Nature is overflowing with inspiring solutions to the world's most wicked problems. We work to understand how knowledge is successfully accessed and how biology is taught to non-specialists.
3) Environmental Ecology: We study mate selection and nest energy dynamics of seabirds and large ocean regime changes though DNA metabarcoding. We are also currently looking at Personal Protective Equipment litter in metropolitan areas.
My research background is on biology education, evolutionary medicine, and biocultural anthropology. Some of the themes I work on are: 1) student network formation in undergraduate classrooms and their impacts on learning; 2) the evolution of human social learning; and, 3) equity and biases in STEM and academic biology.Learn More
My lab studies:
1) Large-scale genome evolution, with a focus on the "C-value enigma," transposable elements, and whole-genome duplications.
2) DNA quantification methods to measure nuclear DNA content.
3) DNA-based methods for species identification and questions in evolutionary biology to understand how biological diversity arises at all levels.
4) Genome size evolution to understand the operation of natural selection and other evolutionary principles.
5) The interface between Integrative Genomics and Evolutionary Biology, otherwise disconnected fields within the biological sciences.
One of the fundamental questions in plant biology concerns the nature of the signals that bring about the transition from vegetative to reproductive growth. My research is aimed at characterizing the developmental signals that cause plants to flower. The primary focus of this work is the maize indeterminate gene (id1). Maize plants that lack id1 function flower extremely late, or not at all, and they exhibit abnormal flower development. The ID1 protein contains zinc-finger motifs, suggesting that it regulates the expression of other genes. Expression analysis reveals that id1 mRNA is expressed only in leaf tissue, suggesting that ID1 acts by controlling the production of leaf-derived signals that mediate the transition to flowering.Learn More
Research in our laboratory is focused on defining eukaryotic signal transduction pathways, and investigating how mutations in components of these pathways can contribute to human disease. Signal transduction is a central process in multicellular organisms that allows for the exchange of informational cues between and within cells. Current areas of research include: 1) Signalling pathways controlling kidney podocyte morphology; 2) focal adhesion dynamics in cancer cells; and, 3) characterization of a novel neuronal adaptor protein, ShcD.Learn More